Benedict presided over an evening Mass at St. Peter's Basilica in which he recalled how beloved John Paul was, particularly among young Catholics.
"How many priestly vocations ... are linked to the testimony and preaching of my venerated predecessor!" Benedict said in urging young people to continue joining the priesthood and religious life.
Later, he was to pray before John Paul's tomb in the grottos underneath St. Peter's.
The pope told Polish pilgrims on Wednesday he was praying for John Paul's beatification, the first step to possible sainthood.
Only a month after John Paul's death in 2005, Benedict put him on the fast track for sainthood by waiving the usual five years before a person's life and works can be examined.
Vatican officials say the process is taking its course, and the required miracle has been identified for examination.
The possible miracle involves the curing of a French nun with Parkinson's disease.
Cardinal Stanislaw Dziwisz, the personal secretary of the late pope, said "there is always hope" that John Paul II will be announced a saint before the fifth anniversary of his death.
But in an interview with Polish TVN24 television, he said the process must go through all necessary stages "so there can be no doubt."
The head of the Vatican's saint-making office, Archbishop Angelo Amato, said the process already got a boost when Benedict waived the five-year waiting period.
In an interview with Vatican Radio, he said the process must actually be more rigorous and thorough for a pope like John Paul since he was so well-known.
"Promptness doesn't mean speed or superficiality; on the contrary this requires care and professionalism," Amato said.
The parliament in Poland, the pope's homeland, observed a minute of silence Thursday to mark the anniversary.
Masses and prayers were also being held across Poland.
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(Source: AP)