Benedict had never before directly addressed condom use. He has said the Roman Catholic Church is in the forefront of the battle against AIDS.

The Vatican encourages sexual abstinence to fight the spread of the disease.

"You can’t resolve it with the distribution of condoms," the Pope told reporters aboard the Alitalia plane headed to Cameroon, where he will begin a seven-day pilgrimage.

"On the contrary, it increases the problem."

About 22 million people in sub-Saharan Africa are infected with HIV, according to UNAIDS. In 2007, 75% of all AIDS deaths worldwide were there, as well as two-thirds of all people living with HIV.

Rebecca Hodes with the Treatment Action Campaign in South Africa said if the Pope is serious about preventing new HIV infections, he will focus on promoting wide access to condoms and spreading information on how best to use them.

"Instead, his opposition to condoms conveys that religious dogma is more important to him than the lives of Africans," said Hodes.

While she said the pope is correct that condoms are not the sole solution to Africa’s AIDS epidemic, she said they are one of the very few HIV prevention mechanisms proven to work.

Even some priests and nuns working with those living with HIV/AIDS question the church’s opposition to condoms amid the pandemic ravaging Africa.

Africa is the fastest-growing region for the Roman Catholic Church, though it competes with Islam and evangelical churches.

The Pope also said yesterday that he intends to make an appeal for "international solidarity" for Africa in the face of the global economic downturn.

He said while the Church does not propose specific economic solutions, it can give "spiritual and moral" suggestions.

Describing the crisis as the consequence of "a deficit of ethics in economic structures", the Pope said: "It is here that the church can make a contribution."

On the plane, Benedict also dismissed the notion he was facing opposition and isolation within the Church, particularly after an outreach to ultraconservatives that led to his lifting the excommunication of a Holocaust-denying bishop.

"The myth of my solitude makes me laugh," the Pope said, adding he can count on friends and aides whom he sees everyday.

In a letter to bishops released last week, the Pope made an unusual public acknowledgment of Vatican mistakes and turmoil over the rehabilitation of Bishop Richard Williamson.

While acknowledging mistakes were made in handling the affair, Benedict said he was saddened that he was criticised "with open hostility" even by those who should have known better.