The Pontiff, who tweets under the user name @pontifex, wrote seven tweets to his hundreds of thousands of followers.
He thanked his followers for their "generous response" and added " I bless all of you from my heart".
Pope Benedict posed questions including "How can faith in Jesus be lived in a world without hope?" He also made statements including "We can be certain that a believer is never alone. God is the solid rock upon which we build our lives and his love is always faithful."
The tweets were written in eight different languages including Polish, German and Arabic.
But within minutes of his first tweet the Pontiff was subjected to expletives and abuse.
Some Twitter users complained the Pope lives "in a palace" while children beg on streets all over the world. Others asked about clerical child abuse and the Catholic Church's opposition to contraception and married priests.
Some users, many from Ireland, decided the Pope's questions should be answered by ones of their own.
"Satan promised me fortune, fame, and unlimited Diet Coke refills in return for my immortal soul. Care to make a counter offer, @Pontifex?" one wrote.