Only six of the 77 people on the plane, which was carrying members of Brazil's Chapecoense team to the Copa Sudamericana final, survived Monday's crash.
The pope compared the disaster to the 1949 Superga that killed 22 members, including 18 players, belonging to the so-called great Torino team.
"Today I'd like to remember the pain of the Brazilian people for the tragedy of their local team," he said.