Mrs McAleese said those responsible, which includes priests, nuns and Church and state officials, would be reflecting on the Ryan Inquiry's devastating findings.
"It is shocking and shameful that so many children had to endure such appalling suffering and abuse in institutions whose obligation and vocation it was to provide them with safe and loving care," the President said.
"It was an atrocious betrayal of love. My heart goes out to the victims of this injustice, an injustice compounded by the fact that they had to suffer in silence for so long.
"They are deeply courageous people who deserve the understanding and support of all of us at this very difficult time."
Government ministers will hold a special Cabinet meeting in the coming weeks to discuss the commission's report. A full Dail debate is also planned for after the local and European elections in early June.
The President also praised the work of the commission.
"This clear and thorough report has discharged an important public service in bringing these terrible matters to full light," she said.
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