A senior Italian cleric has been charged with laundering millions through the Vatican bank, police say.
The former Vatican accountant and two other people were served with arrest warrants on Tuesday, police said.
Last year, Pope Francis set up a commission to review the bank's activities after a series of scandals.
Italian tax police released a video showing details of the monsignor's luxurious 17-room home in Salerno furnished with valuable antiques.
Vatican investigators are currently going through the bank accounts of many clerics working in areas of southern Italy, where organised crime syndicates operate.
Monsignor Scarano spent several months last year awaiting trial in Rome's Queen of Heaven prison, and was then released to house arrest for health reasons. American financial inspectors appointed by Pope Francis believe the monsignor may not be alone in having used the Vatican bank for money-laundering operations.
Traditionally the Vatican has opposed the right of the Italian judiciary to investigate alleged crimes committed by its officials on the grounds of diplomatic immunity and privilege, reports the BBC's David Willey in Rome.
On Tuesday, police seized some 6.5m euros in bank accounts and real estate, including Monsignor Scarano's luxury apartment in the southern city of Salerno.
Authorities said the latest charges against the cleric related to "false donations", which he allegedly recycled from offshore accounts through the Vatican bank.
Prosecutors allege that Monsignor Scarano got dozens of people to make contributions to a home for the terminally ill in Salerno, and used the money to pay off a mortgage on one of his properties.
Another Catholic priest has also been arrested on charges of laundering and making false statements, officials say.
Monsignor Scarano worked for two decades as a senior accountant in a Vatican department known as Apsa (the Administration of the Patrimony of the Apostolic See).
The division manages the Vatican's real estate holdings and stock portfolios.
The trio's high-profile trial began in early December in Rome.
Officially known as the Institute for the Works of Religion (IOR), the Vatican bank is one of the world's most secretive. It has 114 employees and 5.4bn euros of assets.
The bank is undergoing a major restructuring on the orders of Pope Francis.
He has hired an American financial services company to examine all 19,000 accounts to ensure that international rules against money laundering are being correctly observed.