The Irish Mountain Rescue Association (IMRA) which has members in Ireland north and south revealed its plans with up to 30,000 pilgrims expected to scale the 2500 ft Co Mayo peak.
The pilgrims will include Archbishop Michael Neary of Tuam, commemorating how in 441 St Patrick is said to have spent 40 days and nights fasting on the summit.
The IMRA issued a safety warning ahead of the annual pilgrimage, while the Catholic Church released its plans.
"This pilgrimage has been carried out uninterrupted for over 1,500 years," a Church spokesperson said. "Croagh Patrick has over 100,000 visitors annually with up to 30,000 people expected this weekend."
Pilgrims are urged to bring suitable warm clothing, good footwear, a stick and water and to be mindful of the safety of themselves and others. Mountain Rescuers are also urging caution during the Croagh Patrick climb.
"Mountains present challenges for the prepared and the experienced," an IMRA spokesman said. "The unprepared or inexperienced should not allow their ambition to exceed their ability.
"Conditions can rapidly worsen. A simple slip can render a hill walker immobile."
"If an hour or two from the nearest road a twisted ankle could lead to hypothermia and death. Mountains are very serious places," he said.
The Catholic Church has said Mass will be celebrated for pilgrims every half hour from 8am until 2pm, with an Irish Mass planned for 10am.
Further information on Croagh Patrick can be viewed on the website of the Archdiocese of Tuam
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